Runt-related transcription factor 2 in human colon carcinoma: A potent prognostic factor associated with estrogen receptor
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منابع مشابه
Estrogen-Related Receptor in Human Breast Carcinoma as a Potent Prognostic Factor
Estrogen-related receptor (ERR ) was identified as a gene related to estrogen receptor (ER ) and belongs to a class of nuclear orphan receptors. ERR binds to estrogen responsive element(s) (ERE) and is considered to be involved in modulation of estrogenic actions. However, biological significance of ERR remains largely unknown. Therefore, we examined the expression of ERR in human breast carcin...
متن کاملBreast Carcinoma; Human Epidermal Growth Factor Receptor-2 (HER-2) and Grading Correlation
Introduction: Overexpression of Human Epidermal Growth factor Receptor-2 (HER-2) is one of the most important prognostic and predictive factors of breast cancer, observed in 25% - 30% of breast carcinoma patients leading to poor prognosis and feasible anti HER-2 antibody drugs. The objective of this study was to evaluate the HER-2 frequency in target population and its correlat...
متن کاملOverexpression of Runt-Related Transcription Factor-2 Is Associated with Advanced Tumor Progression and Poor Prognosis in Epithelial Ovarian Cancer
AIM To investigate clinical significance of runt-related transcription factor (RUNX)-2 in epithelial ovarian cancer (EOC). METHODS RUNX2 protein expression and its subcellular localization were detected by immunohistochemistry in 116 patients with EOC. RESULTS RUNX2 protein was predominantly expressed in cell nucleus of EOC tissues. The expression level of RUNX2 in EOC tissues was significa...
متن کاملThe Runt-related transcription factor 1 in prostate cancer-associated fibroblasts.
Although most carcinomas arise from a series of genetic alterations in epithelial cells, cancer is a disease that affects not just the transformed cells themselves, but the entire tissue. During tumor development, reciprocal signaling patterns between the cancer cells and the surrounding tissue are altered in a way that affects tissue architecture and cell fate (1). As a result of signals deriv...
متن کاملEarly growth responsive gene 3 in human breast carcinoma: a regulator of estrogen-meditated invasion and a potent prognostic factor.
Early growth responsive gene 3 (EGR3) is a zinc-finger transcription factor and plays important roles in cellular growth and differentiation. We recently demonstrated estrogen-mediated induction of EGR3 in breast carcinoma cells. However, EGR3 has not yet been examined in breast carcinoma tissues and its significance remains unknown. Therefore, in this study, we examined biological functions of...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2012
ISSN: 0020-7136
DOI: 10.1002/ijc.27525